Our Wired Nerves: The Human Nerve Connectome

Cover
OUR WIRED NERVES
The Human Nerve
Connectome
Copyright
Author’s biography
Preface
Acknowledgments
Abbreviations
Introduction
	The body brain connection: A fully infiltrated body
Elegant wiring: Structural beauty of the peripheral nervous system
	How are nerves structured
	Nodes of excitability
		Biology bites
	Sockets and interfaces: Nerve terminals
		Wired for muscle movement
		Biology bites
		Infiltrated for sensation
		Biology bites
		Neglected autonomic axons
		Biology bites
Constantly think physiology: Structure meets function
	Remarkable conduits
	Action potentials: How the connectome is activated
	Action potentials out of control: Fasciculations, pain and other troubles
	Other things move within axons: Axoplasmic transport
	Do I have good reflexes—What are these?
	Nerves and muscles: The motor units
	Movement and Walking: putting your nerves out there
	Exquisite sensation
	Considering taste
	Sensory nerves, not just bystanders
Irreversible events: How nerves are injured
	Why don’t we hear about these?
	What kinds of nerve injuries are there?
	If a nerve injury occurs, this is the type you might prefer
	Nerve damage that does not recover well
	Nerve damage that rarely recovers
Are there nerves? How to test the peripheral nervous system
	The neurological examination: Honed classicism
	Diagnostic shocks and needles
	Imaging portions of nerves
	Chop it out: Biopsy of a nerve
	Detective work: What blood can tell us about nerves
What are neuropathies?
	Mononeuropathies in humans: Intense pain and disability
	What are polyneuropathies: Curious, common and various?
		Diabetes mellitus and nerves
		More types of diabetic nerve damage
		Curing diabetic neuropathy in rodents
		Polyneuropathies with inflammation
			Leprosy
			Guillain-Barré syndrome
			CIDP
		Bolton’s neuropathy (critical illness polyneuropathy)
		Other “acquired” polyneuropathies
		Polyneuropathies you inherit
Locked in
The disrupted connectome and pain
Hope and change: Regrowth of nerves
	The adult nervous system is remodelling
	First clean the mess
	Take my hand: Growth cones that lead the axon
	What does snake venom and mouse salivation have to do with nerves?
	Playing with fire: Inflammation and damaged nerves
	Neuron HQ central and damaged axons
	Are there new neurons?
	What is collateral sprouting
	Persuading neurons not to be boring
	Behaving like a baby: Developmental molecules for regeneration
	Making new nerves: Summarizing the steps
Clinics and biology: Nerve heroes and the Peripheral Nerve Society
Conclusions
References
Index
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